TABLE 3.
Clinicopathologic characteristics in 28,593 patients with primary invasive cutaneous melanoma by tumor size
| Characteristics |
Total n = 28,593 (100) |
Tumor size | ||||
|---|---|---|---|---|---|---|
|
≤6 mm n = 5893 (20.6) |
7‐12 mm n = 9785 (34.2) |
13‐30 mm n = 9323 (32.6) |
31‐42 mm n = 1133 (4.0) |
>42 mm n = 2459 (8.6) |
||
| Age (y) | 61 (50‐72) | 59 (47‐69) | 60 (49‐71) | 64 (53‐74) | 65 (54‐76) | 62 (52‐72) |
| Tumor size (mm) | 11 (7‐20) | 5 (3‐6) | 10 (8‐10) | 18 (15‐22) | 37 (35‐40) | 80 (55‐142) |
| Thickness (mm) | 1.5 (1.0‐3.2) | 1.2 (0.8‐1.9) | 1.4 (0.9‐2.6) | 2.0 (1.1‐4.5) | 3.1 (1.2‐7.0) | 1.9 (1.0‐3.2) |
| Follow‐up (mo) | 45 (19‐86) | 57 (25‐94) | 48 (21‐89) | 40 (17‐77) | 27 (11‐61) | 41 (15‐92) |
| Sex | ||||||
| Female | 11 116 (38.9) | 2634 (44.7) | 3909 (39.9) | 3252 (34.9) | 416 (36.7) | 905 (36.8) |
| Male | 17 477 (61.1) | 3259 (55.3) | 5876 (60.1) | 6071 (65.1) | 717 (63.3) | 1554 (63.2) |
| Primary site | ||||||
| Limbs | 13 698 (47.9) | 2926 (49.7) | 4812 (49.2) | 4342 (46.6) | 506 (44.7) | 1112 (45.2) |
| Trunk | 9253 (32.4) | 1619 (27.5) | 3128 (32.0) | 3250 (34.9) | 386 (34.1) | 870 (35.4) |
| Head/neck | 5566 (19.5) | 1334 (22.6) | 1829 (18.7) | 1702 (18.3) | 236 (20.8) | 465 (18.9) |
| Overlapping | 31 (0.1) | 6 (0.1) | 7 (0.1) | 12 (0.1) | 2 (0.2) | 4 (0.2) |
| Skin | 45 (0.2) | 8 (0.1) | 9 (0.1) | 17 (0.2) | 3 (0.3) | 8 (0.3) |
| Histopathology | ||||||
| Superficial | 8144 (28.5) | 1742 (29.6) | 3031 (31.0) | 2624 (28.1) | 235 (20.7) | 512 (20.8) |
| Nodular | 5571 (19.5) | 973 (16.5) | 1771 (18.1) | 1997 (21.4) | 300 (26.5) | 530 (21.6) |
| Lentigo | 691 (2.4) | 139 (2.4) | 238 (2.4) | 244 (2.6) | 32 (2.8) | 38 (1.5) |
| Acral | 703 (2.5) | 74 (1.3) | 146 (1.5) | 341 (3.7) | 65 (5.7) | 77 (3.1) |
| Others | 13 484 (47.2) | 2965 (50.3) | 4599 (47) | 4117 (44.2) | 501 (44.2) | 1302 (52.9) |
| Mitotic rate (/mm2) | ||||||
| <1 | 2970 (10.4) | 727 (12.3) | 1139 (11.6) | 888 (9.5) | 78 (6.9) | 138 (5.6) |
| ≥1 | 12 609 (44.1) | 2511 (42.6) | 4368 (44.6) | 4317 (46.3) | 526 (46.4) | 887 (36.1) |
| Unknown | 13 014 (45.5) | 2655 (45.1) | 4278 (43.7) | 4118 (44.2) | 529 (46.7) | 1434 (58.3) |
| Ulceration | ||||||
| No | 19 692 (68.9) | 4886 (82.9) | 7266 (74.3) | 5597 (60.0) | 511 (45.1) | 1432 (58.2) |
| Yes | 8901 (31.1) | 1007 (17.1) | 2519 (25.7) | 3726 (40.0) | 622 (54.9) | 1027 (41.8) |
| No | 21 445 (75.0) | 4999 (84.8) | 7830 (80.0) | 6463 (69.3) | 601 (53.0) | 1552 (63.1) |
| Yes | 7148 (25.0) | 894 (15.2) | 1955 (20.0) | 2860 (30.7) | 532 (47.0) | 907 (36.9) |
| Distant metastasis | ||||||
| No | 27 845 (97.4) | 5830 (98.9) | 9663 (98.8) | 9067 (97.3) | 1040 (91.8) | 2245 (91.3) |
| Yes | 748 (2.6) | 63 (1.1) | 122 (1.2) | 256 (2.7) | 93 (8.2) | 214 (8.7) |
P values are based on Pearson Chi‐square test for categorical variables and Kruskal‐Wallis rank‐sum test for non‐normally distributed continuous variables; all P < .001.