Fig. 1. Study design overview.
Note. Participants receive 12, 60-min sessions of cognitive-behavioral therapy (CBT) for alcohol use disorder (AUD) and either NAC (2400 mg/day, dosed as 1200 mg twice daily) or placebo. Twice weekly visits occur during the treatment phase (weeks 1–12). Follow-up visits occur at 3, 6 and 12 months post-treatment.