Table 1.

Assessment Instruments and Timeline.

Instrument name	Purpose/domain	Baseline	Weekly	End of treatment	Follow up
Informed consent	Obtain informed consent	X
Demographics form	Characterize sample	X
History and physical examination	Assess medical problems & eligibility	X
MINI interview for DSM-5	Assess AUD and other DSM-5 psychiatric disorders	X
Columbia-suicide severity rating scale: CSSRSa	Assess suicidality & eligibility	X	Week 6	X	X
Pregnancy test for female subjectsb	Assess for pregnancy	X	Week 6
Clinical institute withdrawal assessment of alcohol-revised: CIWA	Study eligibility, safety	X
Urine drug screen tests: UDSa	Assess drug use	X	Week 6	X	X
Breathalyzer	Assess alcohol use (biological)	X	X	X	X
Adverse events	Monitor AEs and safety	X	X	X	X
Vital signs	Blood pressure and heart rate	X	X	X
Concurrent medications form	Monitor medications	X	X	X	X
Medication adherence log	Assess medication compliance		X	X
Urine riboflavin testa	Biomarker of medication compliance		Week 6	X
Clinician administered PTSD scale: CAPS-5a	PTSD diagnosis and symptoms (clinician rated)	X	Week 6	X	X
PTSD checklist: PCL-5	PTSD symptoms (self-report)	X	X	X	X
Timeline follow-back: TLFB	Assess alcohol use (amount and frequency)	X	X	X	X
Obsessive compulsive drinking scale: OCDS	Measure alcohol craving	X	X	X	X
Visual analog scale: VAS	Assess alcohol craving	X	X	X	X
Alcohol use disorders identification test: AUDIT	Assess alcohol use and related problems	X			Month 12
Ethyl Glucuronide: EtGa	Biomarker of alcohol use		Week 6	X	X
Beck depression inventory-II: BDI-lI	Measure depression	X	X	X	X
Satisfaction questionnaire	Asses overall satisfaction			X	Month 12
Treatment services review	Monitor services utilization	X	X	X	X

Note. Follow up = 3, 6, and 12 months following treatment.

^aRepeated at week 6.

^bPregnancy test at baseline, before medication initiation, before neuroimaging sessions, and at week 6.