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. 2020 Jun 10;10(6):200051. doi: 10.1098/rsob.200051

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© 2020 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Structure of the yeast CCAN and models of the human CCAN complex bound to CENP-A nucleosome. (a) A schematic of the DNA–microtubule interface, with the CENP-A nucleosome and inner kinetochore highlighted. (b) Structure of the S. cerevisiae Ctf19/CCAN complex containing homologues to human CENP-LN, CENP-HIK and CENP-OPQUR. (c) Cryo-EM structure of one copy of S. cerevisiae Ctf19 (lacking homologues of CENP-M and CENP-TWSX) interacting with CENP-A nucleosome on Widom 601 DNA. In this structure, CENP-N^Chl14 does not contact CENP-A or proximal DNA at the sites described in structures of mammalian CENP-N. (d) Composite model of CCAN (Ctf19 complex/CENP-M/CENP-TWSX) with the CCNC. Structural alignment was performed by aligning the N-terminal domain of the common subunit, CENP-N.