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. Author manuscript; available in PMC: 2021 Jan 14.
Published in final edited form as: Basic Res Cardiol. 2020 Jan 14;115(2):16. doi: 10.1007/s00395-019-0772-8

Figure 2.

Figure 2.

Extracellular vesicles (EVs) improved myocardial oxygenation and microcirculation, and reduced renal and systemic inflammation. (A) Representative blood oxygen-level-dependent (BOLD) magnetic resonance images of the left ventricular (LV) and quantification of R2* index. Levels of monocyte-chemoattractant protein (MCP)-1, tumor necrosis-factor (TNF)-α, interleukin (IL)-6, and IL-1ß in Lean, MetS, MetS+RAS, MetS+RAS+EVs and MetS+EVs in renal vein (RV) (B) and the systemic circulation (C). (D) Respective net release by the stenotic kidney. n=5-6/group. *p<0.05 vs. Lean, †p<0.05 vs. MetS, ‡p<0.05 vs. MetS+RAS.