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Transcriptional network of core clock transcription factors (TFs). (A) A composite illustration of all major regulatory limbs. (B) PER/CRY regulate circadian BMAL1 transcriptional activity. (C) ROR and REV-ERB regulate circadian transcription of BMAL1. (D) D-box TFs enhance circadian amplitude of BMAL1 transcription. (E) Different regulatory limbs regulate one another to further fine tune the clock.
