Figure 4.

Circadian regulation of 3-dimensional chromatin architecture. (A) The DBP promoter undergoes circadian interchromosomal interactions in a BMAL1-dependent manner. (B) Chromatin hubs organized by CCCTC-binding factors (CTCFs) are repositioned to the repressive nuclear laminar environment through circadian interaction with poly ADP-ribose polymerase-1 (PARP-1). (C) Enhancer-promoter loops undergo circadian reorganization. REV-ERB opposes functional enhancer-promoter formation to repress transcription.