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. 2020 Jun 29;13:6191–6202. doi: 10.2147/OTT.S253861

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© 2020 Chen et al.

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UBE2O knockout impairs the TGF-β1-induced EMT process. (A) Overexpression of UBE2O induced EMT-related morphological changes in Tu686 cells. PCR and Western blotting assays were performed to evaluate the expression of EMT markers at the mRNA (B) and protein (C) levels following UBE2O overexpression. (D) Knockout of UBE2O attenuated TGF-β1-induced EMT morphological changes. (E) Knockout of UBE2O impaired TGF-β1-induced changes in cell migratory and invasive ability. (F) Knockout of UBE2O attenuated TGF-β1-induced mRNA changes at the mRNA level changes (*P < 0.05, ***P < 0.001).