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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2020 May 21;29(7):1501–1508. doi: 10.1158/1055-9965.EPI-20-0091

Table 2.

Genetically predicted protein concentrations in association with pancreatic cancer risk that are potentially influenced by previously identified risk SNPs.

Protein Protein full name Protein-encoding gene Region for protein encoding gene Instrument variants Type of pQTL ORa Lower bound 95% CIa Upper bound 95% CIa P-value FDR P-valueb P-value after adjusting for risk SNPsc
P-Selectin P-Selectin SELP 1q24.2 rs74227709
rs6136
rs2519093		 trans
cis
trans 		0.86 0.80 0.92 2.67 × 10−5 1.49 × 10−3 0.32
sE-Selectin E-selectin SELE 1q24.2 rs2519093 trans 0.84 0.80 0.88 4.80 × 10−13 3.68 × 10−11 0.13
B3GN2 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 B3GNT2 2p15 rs2519093 trans 1.97 1.64 2.37 4.80 × 10−13 3.68 × 10−11 0.13
Alkaline phosphatase, intestine Intestinal-type alkaline phosphatase ALPI 2q37.1 rs550057 trans 0.43 0.35 0.53 1.91 × 10−15 4.68 × 10−13 0.56
VEGF sR2 Vascular endothelial growth factor receptor 2 KDR 4q12 rs34231037
rs635634		 cis
trans 		0.80 0.74 0.87 4.86 × 10−8 3.31 × 10−6 0.55
TLL1 Tolloid-like protein 1 TLL1 4q32.3 rs8176747 trans 1.30 1.11 1.52 1.10 × 10−3 3.78 × 10−2 0.60
LIF-sR Leukemia inhibitory factor receptor LIFR 5p13.1 rs635634 trans 0.49 0.41 0.59 2.10 × 10−13 2.57 × 10−11 0.10
gp130, soluble Interleukin-6 receptor subunit beta IL6ST 5q11.2 rs635634
rs11574765		 trans
cis 		0.73 0.63 0.84 2.94 × 10−5 1.57 × 10−3 0.70
GFRAL GDNF family receptor alpha-like GFRAL 6p12.1 rs72975088
rs8176672		 trans
cis 		1.33 1.13 1.57 6.15 × 10−4 3.14 × 10−2 0.47
GP116 Adhesion G protein-coupled receptor F5 ADGRF5 6p12.3 rs2519093 trans 0.76 0.71 0.82 4.80 × 10−13 3.68 × 10−11 0.13
CD36-ANTIGEN Platelet glycoprotein 4 CD36 7q21.11 rs8176693 trans 1.27 1.10 1.46 1.01 × 10−3 3.78 × 10−2 0.61
Met Hepatocyte growth factor receptor MET 7q31 rs635634 trans 0.57 0.49 0.66 2.10 × 10−13 2.57 × 10−11 0.10
sTie-2 Angiopoietin-1 receptor, soluble TEK 9p21.2 rs8176693 trans 1.28 1.10 1.48 1.01 × 10−3 3.78 × 10−2 0.61
Endoglin Endoglin ENG 9q34.11 rs635634 trans 0.41 0.32 0.52 2.10 × 10−13 2.57 × 10−11 0.10
BGAT Histo-blood group ABO system transferase ABO 9q34.2 rs505922 cis 1.20 1.15 1.24 5.74 × 10−21 2.35 × 10−18 NAd
Notch1 Neurogenic locus notch homolog protein 1 NOTCH1 9q34.3 rs8176743 trans 1.46 1.16 1.83 1.10 × 10−3 3.78 × 10−2 0.60
CHST15 Carbohydrate sulfotransferase 15 CHST15 10q26.13 rs550057 trans 0.52 0.44 0.61 1.91 × 10−15 4.68 × 10−13 0.56
CHSTB Carbohydrate sulfotransferase 11 CHST11 12q23.3 rs687621 trans 3.62 2.77 4.74 5.57 × 10−21 2.35 × 10−18 0.46
THSD1 Thrombospondin type-1 domain-containing protein 1 THSD1 13q14.3 rs41292808
rs2519093		 trans
cis 		0.74 0.65 0.83 5.85 × 10−7 3.77 × 10−5 0.13
F177A Protein FAM177A1 FAM177A1 14q13.2 rs550057
rs679574		 Trans
trans 		0.63 0.54 0.73 1.54 × 10−9 1.11 × 10−7 0.45
GLCE D-glucuronyl C5-epimerase GLCE 15q23 rs11854180
rs2519093		 trans
cis 		1.13 1.07 1.19 1.85 × 10−5 1.08 × 10−3 0.44
IGF-IR Insulin-like growth factor 1 receptor IGF1R 15q26.3 rs635634 trans 0.38 0.29 0.49 2.10 × 10−13 3.22 × 10−11 0.10
Cadherin-5 Cadherin-5 CDH5 16q21 rs8176746 trans 1.12 1.05 1.20 1.10 × 10−3 3.78 × 10−2 0.60
Desmoglein-2 Desmoglein-2 DSG2 18q12.1 rs2704050
rs687621		 trans
cis 		1.88 1.59 2.23 3.31 × 10−13 3.67 × 10−11 0.99
IR Insulin receptor INSR 19p13.2 rs507666 trans 0.69 0.63 0.77 3.59 × 10−13 4.40 × 10−11 0.12
DC-SIGN CD209 antigen CD209 19p13.2 rs505922 trans 1.32 1.25 1.40 5.74 × 10−21 2.35 × 10−18 NAd
JAG1 Protein jagged-1 JAG1 20p12.2 rs7041
rs550057		 trans
trans 		0.70 0.59 0.82 9.08 × 10−6 7.95 × 10−4 0.41
FAM3B Protein FAM3B FAM3B 21q22.3 rs2608894
rs73226194
rs2519093		 cis
trans
trans 		1.15 1.06 1.25 8.01 × 10−4 3.78 × 10−2 0.64
IL-3Ra Interleukin-3 receptor subunit alpha IL3RA Xp22.3 rs2519093 trans 0.78 0.73 0.84 4.80 × 10−13 4.90 × 10−11 0.13
C1GLC C1GALT1-specific chaperone 1 C1GALT1C1 Xq24 rs7787942
rs2519093		 trans
trans 		1.39 1.28 1.50 5.34 × 10−15 1.09 × 10−12 3.02 × 10−3
a

OR (odds ratio) and CI (confidence interval) per one standard deviation increase in genetically predicted protein after adjustment for age, sex, and top 10 principle components.

b

FDR P-value: false discovery rate (FDR) adjusted P-value; associations with a FDR p≤0.05 considered statistically significant.

c

Associations were adjusted for risk SNPs include: rs2816938, rs3790844, rs1486134, rs2736098, rs35226131, rs401681, rs17688601, rs78417682, rs6971499, rs2941471, rs10094872, rs1561927, rs505922, rs9581943, rs9543325, rs4795218, rs11655237, rs1517037.

d.

Instrument SNP itself is a known PC risk SNP.