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. Author manuscript; available in PMC: 2020 Jul 4.
Published in final edited form as: Cancer Discov. 2020 May 6;10(7):1038–1057. doi: 10.1158/2159-8290.CD-19-1242

Figure 6. Apc mutations drive disease and metastatic progression in prostate cancer organoid models.

Figure 6.

(A) Representative gross bright field (top) and H&E (bottom) images of prostates of NOD-scid IL2Rγnull (NSG) mice 15 weeks after orthotopic transplantation of prostate organoids with indicated genotypes.

(B) Representative immunohistochemical staining of prostates of NSG mice 15 weeks after orthotopic transplantation of prostate organoids with indicated genotypes.

(C-D) Representative bioluminescence images of NSG mice 4 weeks after tail vein injection of mouse prostate organoids with indicated genotypes (n=3–4).