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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Clin Cancer Res. 2020 Apr 2;26(13):3384–3396. doi: 10.1158/1078-0432.CCR-19-3487

Figure 5. Cytotoxic activity of nano-aAPC expanded CD8+ T-cells against melanoma cell lines.

Figure 5.

(A) Specific lysis of CD8+ T-cells were analyzed. CD8+ T-cells were co-cultured with melanoma cell lines SK-MEL-28 (HLA-A*0201−, MART-1+), A375 (HLA-A*0201+, MART-1−), MeWo (HLA-A*0201+, MART-1+), Malme-3M (HLA-A*0201+, MART-1+) at various ET ratios. Significance was assessed by Student’s two-tailed t test at ET=10. (B) Specific lysis of nano-aAPC expanded CD8+ T-cells against MeWo at ET=10 comparing with unexpanded CD8+ T-cells from 5 melanoma patients. Error bars indicate mean ± SD. Significance was assessed by Student’s two-tailed paired t test.