Table 3.
Inhibition of the enzymatic activity of Catepsin B from L. braziliensis.
| Compound | Time (minutes) |
||||||
|---|---|---|---|---|---|---|---|
| 1 | 5 | 10 | 15 | 20 | 25 | 30 | |
| TC1 | 36.7 ± 2.6 | 35.0 ± 2.4 | 34.9 ± 3.2 | 33.8 ± 2.5 | 33.4 ± 2.5 | 32.5 ± 2.6 | 32.0 ± 2.6 |
| TC2 | 19.1 ± 7.0 | 18.6 ± 9.4 | 17.5 ± 1.1 | 15.3 ± 9.9 | 15.0 ± 1.2 | 14.2 ± 1.2 | 12.9 ± 1.3 |
| SS | 19.4 ± 8.3 | 17.6 ± 9.8 | 16.0 ± 1.0 | 14.1 ± 1.1 | 12.7 ± 1.2 | 11.4 ± 1.3 | 9.7 ± 1.4 |
| DMSO | 17.7 ± 5.7 | 16.2 ± 6.6 | 14.4 ± 6.7 | 12.2 ± 7.8 | 11.0 ± 7.9 | 9.4 ± 1.8 | 8.2 ± 0.4 |
| CA074 | 84.6.2 ± 9.9 | 83.4 ± 7.9 | 83.2 ± 1.4 | 82.5 ± 1.3 | 82.0 ± 1.3 | 81.5 ± 1.5 | 81.1 ± 1.7 |
Data show the % inhibition of the enzymatic activity of cathepsin B after 2 h of exposure to 50 μg/mL of each compound.