Table 4.

Residue types at hypervariable positions for WT VH9 and mutant VH9 optimized for MDM4

	30	31	32	33	53	94	95	96	97	98	99	100	101	102	104
WT	GLU	GLU	TYR	ALA	ALA	TYR	TYR	CYS	ALA	LYS	PRO	TRP	TYR	PRO	MET
Mutant	GLU	TYR	THR	ARG	HIS	TYR	SER	GLY	GLY	TYR	ARG	TYR	ARG	GLY	ASP