Acute osteomyelitis is clinically challenging to treat as it is commonly caused by Gram-positive pathogens, particularly resistant Staphylococcus, and antibiotic treatment requires multiple daily doses, therapeutic monitoring, and parenteral administration for multiple weeks.

In real-world clinical use, oritavancin doses of 1200 mg and then 800 mg once per week for 4–5 weeks for treatment of acute osteomyelitis showed positive clinical outcomes—high rate of clinical success and low rate of adverse events.