Fig. 4.
Neutralization of SHIV162P3 cell-cell transmission by a panel of 2nd-generation bNAbs in a PBMC based assay. bNAbs were used singularly (a) or in combination (b, c). Infection was analyzed by SIV p27 Ag ELISA seven days post-coculture. The mean and SEM of three to four independent experiments is shown. Dotted lines indicate 0, 50 and 90% inhibition of viral transmission. Antibodies targeting the V3 (10–1074 and PGT128), the bridging region (PGT151), the CD4bs (N6 and 3BNC117), the MPER (10E8) and the V1/V2 (PG16 and PGDM1400) were used.