Figure 4.
The SH2B3 Locus Shows Associations with Breast Cancer Risk and Immune Cell Features
(A) Graph showing the chromosome 12 association results (-log10 p value, y axis) with breast and ovarian cancer risk (as depicted in the inset) in women carriers of BRCA1/2 mutations. The rs3184504 and rs11065979 variants are indicated.
(B) Rank of expression correlations (Pearson's correlation coefficients [PCCs]) between SH2B3 and immune/cell signatures in normal breast. All PCCs were >0, but three of them did not reach nominal significance (marked gray).
(C) Positive correlation between SH2B3 expression in normal breast and age of diagnosis of breast cancer. The trend lines for all cases and subtypes (luminal, HER2-positive, and triple-negative breast cancer [TNBC]) are shown. The correlation p value from the multivariate regression analysis is shown.
(D) Positive correlation between SH2B3 functionally related gene set in normal breast and age of diagnosis of breast cancer.
(E) Positive correlation between SH2B3 expression and CD26 and TFRC protein expression as measured by TCGA reverse-phase protein array (RPPA) assays. The correlation p value from the multivariate regression analysis is shown.