Table 1.

Changes in the Metabolite Levels in Skeletal Muscle in KO Compared to WT Mice

Compound	KO/WT-f 3–4 Months Old	KO/WT-m 5–6 Months Old	KO/WT-f 8–9 Months Old
Glycolysis
G1P	0.8	0.6∗∗	0.6∗
G6P	0.9	0.7∗∗∗	0.8∗
Fructose 6-phosphate	0.8	0.7∗∗∗	0.7∗∗
Fructose 1,6-diphosphate	0.9	0.5∗∗	0.7
3-Phosphoglyceric acid (3PG)	0.8	0.6∗∗∗	1.0
2-Phosphoglyceric acid (2PG)	0.8	0.6∗∗∗	1.0
Pyruvic acid	0.8∗	0.8∗∗∗	0.7
Lactic acid	0.7∗∗	0.7∗∗	0.7∗
Acetyl-CoA	1.3∗∗	1.4∗	1.7∗
TCA (Krebs Cycle)
Citric acid	1.7∗∗∗	1.1∗	1.4∗∗∗
Cis-aconitic acid	-	1.8∗	1.5∗
Succinic acid	1.2	1.3	1.6∗
Fumaric acid	1.5∗∗	1.9∗∗	1.8∗
Malic acid	1.2	1.6∗∗	1.4
Carnitine	1.9∗∗∗	1.5∗∗∗	1.4∗∗∗
Glycogen Synthesis Precursors
Galactose 1-phosphate	2.0∗∗	1.7	2.8∗∗
UDP-glucose	1.7∗∗∗	1.6∗∗∗	1.6∗