Figure 8.

In Vitro and In Vivo Degradation Behavior of ND Nanozymes

(A–J) (A) Time-dependent biodistribution and (B) excretion patterns at different time points post i.v. injection with the ND nanozymes (dose: 10 mg/kg). (C) UV-vis-NIR absorption spectra of ND nanozymes in pure water over time. (D) The degradation rate of ND nanozymes in different physiological solutions (pure water, normal saline, PBS, PBS pH = 6.5, RPMI containing 10% serum) on the sixth day. (E) Photographs of ND nanozymes in physiological solutions at various time points. (F) TEM images of ND nanozymes in pure water on the 0 and fourth day. (G–I) XPS spectra of ND nanozymes in pure water on the fourth day; core level spectra of (G) Ni 2p, (H) S 2p, and (I) O 1s. (J) The degradation mechanism of ND nanozymes in vivo.

See also Figures S11 and S12.