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. 2020 Jun 17;117(26):15066–15074. doi: 10.1073/pnas.1920049117

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Fig. 1. — Short telomeres promote tumorigenesis in a noncell autonomous manner. (A) Experimental setup for the generation of zebrafish chimeras. Donor cells are transplanted from a Tg(mitfa:HRAS^G12V; β-actin:GFP) embryo at the blastula stage into embryos resulting from an in cross of tert^+/−; casper zebrafish. (B) Representative images of adult chimera zebrafish harboring melanoma in either WT or tert^−/− recipients. (C) Melanoma occurrence over time in chimeric fish. tert^−/− recipient fish have a higher risk of tumorigenesis than WT and het recipient fish. *P < 0.05.