Fig. 3.

Volunteer HP-¹³C kinetic data. Maps of k_PL and k_PB from the third scan of healthy volunteer HV3 overlaid on T₁-weighted images, which illustrate the spatial variation of apparent HP [1-¹³C]pyruvate metabolism: 1, cortex/grey matter; 2, white matter; 3, cuneus; and 4, putamen/deep grey matter (A). Healthy volunteer values of k_PL-NAWM (B) and k_PB-NAWM (C) are shown together with nonlinear least squares fitting error for 3 subjects over scan intervals of 30 min (a), 107 days (b) and 67 days (c).