Fig. 5.

Profiles of progression. Imaging at the time of radiologically-defined progression shown using k_PL maps overlaid on T₂-weighted FLAIR and post-gadolinium T₁-weighted images. Patient P5 demonstrated elevated k_PL in the lesion that was spatially heterogeneous, with higher values in and around the CEL compared to the surrounding T2L (A); whereas patient P2 showed uniformly elevated k_PL that extended distally from the CEL into the T2L, as indicated by the white arrow (B). Diffusely elevated k_PL in patient P4 corresponded with a large non-enhancing T2L centered in the corpus callosum and extending to the left frontal white matter and cortex (white arrows) (C). In each case, the lesion k_PL highlighted radiological progression.