Fig. 2.

SS-31 interactome. (A) Nodes represented by colored circles indicate the 12 proteins cross-linked to bSS-31. UniProt identifiers are labeled on the nodes along with the lysine residues that were identified as cross-linked to bSS-31. All 12 proteins are known to interact with cardiolipin (CL, red). The proteins are grouped into two major classes: ATP processes (Upper light blue area) and 2-oxogluterate processes (Lower light purple area). (B) Schematic representation of SS-31 peptide cross-linked proteins within the mitochondria. These proteins include creatine kinase (KCRS), ADP/ATP translocase (ADT1), complex III (CIII) subunits QCR2 and QCR6, complex IV (CIV) subunit NDUA4, complex V (CV) subunits ATPA and ATPB, trifunctional enzyme subunit (ECHA), aspartate aminotransferase (AATM), isocitrate dehydrogenase (IDHP), and 2-oxogluterate dehydrogenase complex subunits ODO1 and ODO2. bSS-31 peptide is represented by a blue rectangle with yellow triangle.