Table 9.

Risk of bias summary of all five randomized clinical trials evaluating the addition of aripiprazole for lowering prolactin.

Bias	Shim et al., 2007	Chen et al., 2015	Zhao et al., 2015	Qiao et al., 2016	Kelly et al., 2018
Random sequence generation	unclear	low	unclear	unclear	low
Allocation concealment	unclear	low	unclear	unclear	low
Blinding of participants and researchers†	low	low	low	low	low
Blinding of outcome assessment†	low	low	low	low	low
Incomplete outcome data	low	low	low	low	low
Selective reporting	low	low	low	low	low
Other bias	low	low	low	low	low
Quality of the clinical trial	fair	good	fair	fair	good

^†As primary outcome was change in plasma concentrations of prolactin, all randomized clinical trials were considered to have a low risk of bias with respect to the outcome, as this is an objective measure unlikely to be biased even in unblinded situations.