Fig. 1.

Processing pipeline. To compare patient and control groups or patients with different postoperative outcome, two complementary analyses were performed. (A) A connectometry analysis which is sensitive to changes in subsections of bundles was employed to investigate local differences within bundles: Connnectometry identified subsections within bundles in the whole brain where QA changes over time were significantly different between groups. (B) A graph theory approach was applied to integrate connectivity across the wider brain network: To produce connectivity matrices, mean QA along the bundles of the connectome atlas connecting each pair of AAL regions was computed for each subject. Graph theory was used to compare changes in network properties over time. Resected tissue mask: The resected tissue masks of all patients were overlaid in a single mask to be used as region of avoidance in (A) and (B). When comparing patient and control groups, that single mask was applied in both groups to restrict the analyses to the same non-resected brain area.