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. 2020 Jun 20;23(7):101293. doi: 10.1016/j.isci.2020.101293

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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RNA Sequencing and Differential Gene Expression Analysis Provide Insight into States of Collateral Sensitivity and Resistance

Left: The temporal collateral sensitivity map from Figure 2, where all samples that were not sequenced are overlayed with gray. Right: Two waterfall plots representing the samples ranked by their responses to the two drugs, vorinostat (SAHA, top) and SP-2509 (SP, bottom). Sample labels on the x axis are represented by darker colors the longer they have been evolved in the evolutionary experiment.