Figure 1.

The Dysregulation of Ferroptosis Regulator Genes (FRGs)

For which the positive and negative regulators are marked in red and blue, respectively.

(A) Histogram shows the frequency of somatic copy number alterations for each FRG in each cancer type.

(B) Histogram (upper panel) shows the number of significantly differentially expressed genes, and the heatmap shows the fold change and FDR of FRGs in each cancer. Significantly upregulated and downregulated genes are marked in red and green, respectively.

(C) The Spearman's correlation between somatic copy number alterations and the expression of FRGs.

(D) Heatmap shows the differential methylation of FRGs in cancers; hypermethylated and hypomethylated genes are marked in red and blue, respectively (Wilcoxon rank-sum test).

(E) Pearson's correlation of FRGs between transcriptional expression and promoter methylation. Red and blue represent positive and negative correlations, respectively.

(F) The miRNA-mRNA network for FRGs, the orange and green circles are positive and negative FRGs, respectively (Spearman's Rho < −0.1, FDR <0.05).