Figure 1.

Sennoside A reduced the blood glucose level and fat accumulation in db/db mice. (a) Glucose level, (b) HOMA-IR, (c) body weight, and (d) tissue weight of db/db mice during the 12 weeks with or without Sennoside A treatment. (e) Representative hematoxylin and eosin-stained pictures of EAT deposits (n = 5 images per mouse). Scale bar: 200 μm. (f) Adipocyte size distribution determined from histomorphometry and image analysis of EAT. Data were presented as means ± SD (n = 10 mice per group). Statistical analysis was performed using one-way analysis of variance followed by Kruskal-Wallis test. Significance: ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001 versus control.