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. 2020 Jun 25;2020:2375676. doi: 10.1155/2020/2375676

Figure 6.

Figure 6

Fecal transplantation of Sennoside A reversed the obesity and T2D-related traits. Mice received a weekly microbiota transplant either from control donor mice (Ctrl-Ctrl) or from Sennoside A (50 mg/kg) donor mice (Sen-Ctrl). Fecal microbiota transplantation (FMT) reversed obesity and blood glucose levels of db/db mice during the 8-week treatment (n = 5 per group). (a) Glucose level, HOMA-IR (b), and body weight (c) of db/db mice with FMT during 8 weeks. (d) TG and TC of db/db mice. (e) FFA of db/db mice. (f) Representative photos of the liver (scale bar: 1 cm) and EAT (scale bar: 1 cm). Weights of the liver and EAT. (g) FMT reduced the expressions of proinflammatory genes in db/db mice (n = 5 per group). Relative mRNA expression levels of proinflammatory genes TNF-α, IL-6, F4/80, and MCP-1 in the liver and EAT. (h) FMT prevented a leaky gut as shown in what are representative ileum immunoblots of ZO-1 and occludin.