Table 2.
Information on AD-related targets.
| Gene | Target name | UniProt ID |
|---|---|---|
| ABCA1 | ATP-binding cassette subfamily A member 1 | O95477 |
| ABCB1 | Multidrug resistance protein 1 | P08183 |
| ACHE | Acetylcholinesterase | P22303 |
| ADH1C | Alcohol dehydrogenase 1C | P00326 |
| ADRA2C | Alpha-2C adrenergic receptor | P18825 |
| ADRB2 | Beta-2 adrenergic receptor | P07550 |
| AHR | Aryl hydrocarbon receptor | P35869 |
| ALOX5 | Arachidonate 5-lipoxygenase | P09917 |
| APP | Amyloid beta A4 protein | P05067 |
| BACE1 | Beta-secretase 1 | P56817 |
| BAX | Apoptosis regulator BAX | Q07812 |
| BCHE | Cholinesterase | P06276 |
| BCL2 | Apoptosis regulator Bcl-2 | P10415 |
| CALM1 | Calmodulin | P0DP23 |
| CASP3 | Caspase-3 | P42574 |
| CASP7 | Caspase-7 | P55210 |
| CDK5 | Cyclin-dependent kinase 5 (CDK5) | Q00535 |
| CHRM1 | Muscarinic acetylcholine receptor M1 | P11229 |
| CHRM2 | Muscarinic acetylcholine receptor M2 | P08172 |
| CHRM3 | Muscarinic acetylcholine receptor M3 | P20309 |
| CHRNA2 | Neuronal acetylcholine receptor subunit alpha-2 | Q15822 |
| CHRNA7 | Neuronal acetylcholine receptor protein, alpha-7 chain | P36544 |
| CHUK | Inhibitor of NF-kappa-B kinase (IKK) | O15111 |
| CYP1A2 | Cytochrome P450 1A2 | P05177 |
| CYP2A6 | Cytochrome P450 2A6 | P11509 |
| CYP2D6 | Cytochrome P450 2D6 (2D6) | P10635 |
| CYP3A4 | Cytochrome P450 3A4 | P08684 |
| DIO1 | Type I iodothyronine deiodinase | P49895 |
| ESR1 | Estrogen receptor | P03372 |
| F2 | Thrombin | P00734 |
| F7 | Coagulation factor VII | P08709 |
| FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 |
| GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | P14867 |
| GABRA2 | Gamma-aminobutyric-acid receptor alpha-2 subunit | P47869 |
| GABRA5 | Gamma-aminobutyric-acid receptor alpha-5 subunit | P31644 |
| GSK3B | Glycogen synthase kinase-3 beta | P49841 |
| HMOX1 | Heme oxygenase 1 | P09601 |
| HTR2A | 5-Hydroxytryptamine 2A receptor | P28223 |
| IGF1R | Insulin-like growth factor 1 receptor | P08069 |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | O14920 |
| IL10 | Interleukin-10 | P22301 |
| IL1B | Interleukin-1 beta | P01584 |
| INS | Insulin | P01308 |
| INSR | Insulin receptor | P06213 |
| KDR | Vascular endothelial growth factor receptor 2 | P35968 |
| MAOA | Amine oxidase [flavin-containing] A | P21397 |
| MAOB | Amine oxidase [flavin-containing] B | P27338 |
| MAPK10 | Mitogen-activated protein kinase 10 | P53779 |
| MET | Hepatocyte growth factor receptor | P08581 |
| NOS3 | Nitric-oxide synthase, endothelial | P29474 |
| NR1I2 | Nuclear receptor subfamily 1 group I member 2 | O75469 |
| PLAU | Urokinase-type plasminogen activator | P00749 |
| PPARG | Peroxisome proliferator activated receptor gamma | P37231 |
| PTGES | Prostaglandin E synthase | O14684 |
| PTGS1 | Prostaglandin G/H synthase 1 | P23219 |
| PTGS2 | Prostaglandin G/H synthase 2 | P35354 |
| RXRA | Retinoic acid receptor RXR-alpha | P19793 |
| RXRG | Retinoic acid receptor RXR-gamma | P48443 |
| SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4 | P14672 |
| SOAT1 | Acyl-cholesterol acyltransferase 1 | P35610 |
| TNF | Tumor necrosis factor | P01375 |
| VEGFA | Vascular endothelial growth factor A | P15692 |