Fig. 7.

Facets of longitudinal protein variability. Protein profiles were stratified by their longitudinal profiles. (A) Venn Diagram indicates the number of observations (protein per individual) that was deviating (± 3xSD) from the population mean in terms of protein baseline, trend and fluctuations. Here, we selected 14 protein profile examples. Each grey line represents one individual. One selected individual with a particular protein profile is highlighted in red, and the category of the red profile is marked on the left side of the protein name. (B) Distribution of the three annotation criteria per subject, and (C) the sum of the three annotation criteria per individual (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).