Table 1.
Circulating proteins with cis-pQTLs.
| Protein | Antibody† | P‡ | Top SNP‡ | Variant* | TwinGene P§ |
|---|---|---|---|---|---|
| CLEC3B | HPA034794 | 5.31 × 10−38 | rs4683026 | Gly - Ser | n.a. |
| HRG | Bsi0137 | 3.65 × 10−25 | rs12493926 | Asn - Ile | < 1 × 10−300 |
| C1R | HPA001551 | 2.18 × 10−22 | rs1801046 | Leu - Ser | n.a. |
| GC | Bsi0185 | 8.13 × 10−20 | rs843005 | Asp - Glu | 1.17 × 10−95 |
| CFH | MAB4779 | 7.60 × 10−17 | rs61818923 | n.a. | |
| CFH | Bsi0885 | 1.81 × 10−16 | rs1048663 | Glu - Asp | 8.96 × 10−269 |
| AGT | HPA001557 | 3.26 × 10−16 | rs4762 | Thr - Met | n.a. |
| F9 | HPA000254 | 5.16 × 10−16 | rs422187 | Thr - Ala | n.a. |
| F12 | Bsi0849 | 1.25 × 10−14 | rs1801020 | 7.62 × 10−126 | |
| C4A | OASA01015 | 5.15 × 10−14 | rs386480 | n.a. | |
| LRG1 | Bsi3134 | 8.50 × 10−10 | rs10426311 | n.a. | |
| C6 | Bsi0731 | 3.88 × 10−9 | rs7443604 | Ala - Glu | 1.67 × 10−71 |
| AHSG | Bsi0907 | 4.58 × 10−9 | rs13073106 | Ser - Thr | 1.24 × 10−16 |
| FGL1 | HPA049320 | 6.83 × 10−9 | rs10093134 | n.a. | |
| HP | Bsi1809 | 1.18 × 10−8 | rs811053 | 4.86 × 10−88 |
†
The ID of the antibodies used in SBA assays.
‡
Top associated SNP by ranking and the nominal P-value for the association (linear regression).
⁎
Non-synonymous SNPs in almost perfect linkage disequilibrium (LD) with the top SNP (R2 ≥ 0.8) in genomic data of Utah residents from north and West Europe (CEU) in the 1000 Genome project. The amino-acid variants were shown after the SNP ID. Additional details are provided in Table S6.
§
GWAS analysis conducted with the TwinGene cohort also revealed significant associations when matching SNPs with those identified in the S3WP study.