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. 2020 Jul 3;18:80. doi: 10.1186/s12915-020-00792-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Enrichment of selection signature across multiple tissues. a The first bar plot is for enrichment of selection signature in tissue-specific H3K4me3 across multiple tissues. The second, third, and fourth ones are for associations of traits with thyroid, vagina, and esophagus, respectively, based on GWAS signal enrichments of tissue-specific H3K4me3. The red line denotes FDR < 0.05. b An example of shared peaks between selection signature (SS) and GWAS of somatic cell scores (SCS). ESR1 gene, which shows tissue-specific H3K4me3 signals in vagina, locates within the peak. c Gene expression of ESR1 in 91 bovine tissues