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. 2020 Jul 3;18:80. doi: 10.1186/s12915-020-00792-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Shared genetic architecture between human diseases/traits and cattle traits. a Correlations of complex traits between human and cattle based on GWAS signal enrichment of tissue-specific H3K4me3 (top 5%) across all tested tissues. “*” denotes FDR < 0.05. b Correlation between age at menopause in human (Human_Age_at_menopause) and daughter still birth (Dtr_Still_Birth) in cattle. c Correlation between allergic disease (Human_Allergic) in human and metritis (Cattle_METR) in cattle. d, e Examples of two genes, PIK3CG and ICAM3, with tissue-specific H3K4me3 in mononuclear cells and T cells, respectively. Dots plots (up) are GWAS peaks within 1 Mb regions of the genes in cattle and human. UCSC browser tracks of genes (down) include transferred H3K27ac, H3K4me3, H3K9ac, H3K36me3, and measured DNA methylation (Meth) data in cattle. Below are the tracks for gene expressions of PIK3CG and ICAM3 in 91 bovine tissues. Green curve lines in d indicate a capture Hi-C contact between PIK3CG and GWAS signal peaks (~ 610 kb upstream) in human and cattle