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. 2020 Sep;10(9):a038398. doi: 10.1101/cshperspect.a038398

Figure 4.

Figure 4.

Replication by the influenza virus RNA polymerase. (A) Synthesis of complementary RNA (cRNA) by the influenza virus RNA polymerase and coreplicative assembly of complementary ribonucleoprotein (cRNP). (B) Synthesis of viral RNA (vRNA) by the influenza virus RNA polymerase and coreplicative assembly of vRNP. Template realignment is promoted by a regulatory polymerase. ANP32A associates with RNA-free RNA polymerase and may regulate dimerization of the RNA polymerase. (C) Schematic model of the influenza virus RNA polymerase showing replication initiation during cRNA synthesis. (D) Schematic model of the influenza virus RNA polymerase showing replication initiation and realignment during vRNA synthesis.