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. 2020 Sep;10(9):a038398. doi: 10.1101/cshperspect.a038398

Figure 5.

Figure 5.

Aberrant RNA synthesis by the influenza virus RNA polymerase. (A) In addition to full-length viral RNAs (vRNAs), the influenza virus RNA polymerase produces defective interfering (DI) RNAs, mini viral RNAs (mvRNAs), and small viral RNAs (svRNAs). (B) Synthesis of DI RNAs and mvRNAs uses an intramolecular copy-choice mechanism. (C) Host-specific mutation in the viral RNA polymerase are linked to mvRNA levels. mvRNAs can be bound by RIG-I and induce RIG-I activation and cytokine expression.