Fig. 2.

Network-based methodology combining pharmacology-based network medicine platform to quantify the interplay between the virus–host interactome and drug targets in the human protein-protein interactions network. a Human coronavirus (HCoV) associated host protein sourced from literature and pooled to generate a protein subnetwork. b Network proximity between drug targets and HCoV-associated proteins that were calculated to screen for candidate repurposability. c, d Gene set utilized to validate the network-based prediction. e Prioritization of top candidates for drug combinations using network based. Reproduced with permission from (Zhu et al., 2020).