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. 2020 Apr 27;152(7):e201912537. doi: 10.1085/jgp.201912537

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© 2020 Wilding and Huettner

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Figure 6. — Cd activates GluA1 A8C/GluA2 heteromeric receptors. (A) Whole-cell currents evoked by 3.2 µM to 10 mM Cd (red bars) or by 100 µM kainate (open bars) in HEK293 cells cotransfected with edited GluA2 and GluA1 A8C. (B) Steady-state Cd-evoked current plotted as a fraction of the maximal Cd-evoked response (mean ± SEM; five cells). Smooth curve is the best fits of I/I max = {1 / [1 + (EC₅₀ / [Cd])ⁿ]} / [1 + ([Cd] / IC₅₀)^b], where EC₅₀ and IC₅₀ are the Cd concentrations producing half-maximal activation and inhibition, respectively; n and b are the slope factors for activation and inhibition.