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Cd reduces holding current in A7C mutant GluK2(Q) or GluA1. (A) Whole-cell current during exposure to 10 µM kainate (open bars) or 100 µM Cd (red bars) in an HEK293 cell transfected with GluK2(Q) A7C. Note the slow recovery from Cd inhibition in the absence and presence of kainate. (B) Current during exposure to 100 µM kainate or 50 µM Cd in a cell cotransfected with GluA1 A7C and γ-2 TARP.
