Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 14;152(7):e201912511. doi: 10.1085/jgp.201912511

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Uwera et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 14. — Replacing Ca²⁺ by Mg²⁺ improved the maximum rate of action potential depolarization in wild type soleus and HyperKPP soleus. Resting E_M values were divided in bins of 5 mV and mean resting E_M and maximum rate of depolarization were averaged. Lines were drawn from a sigmoidal nonlinear regression analysis (except for the 5.2 mM Mg²⁺ in A because a good fit could not be obtained). The inset in B is to illustrate the difference in the relationship at 0.3 mM Ca²⁺ between wild type and HyperKPP muscles. Horizontal and vertical bars represent the SE of 6–47 fibers/6 muscles. *, Mean maximum rate of depolarization significantly different from that at 2.4 mM Ca²⁺. †, Mean maximum rate of depolarization of HyperKPP soleus significantly different from that of wild type. ANOVA and LSD, P < 0.05.