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. 2020 Apr 14;152(7):e201912511. doi: 10.1085/jgp.201912511

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© 2020 Uwera et al.

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Figure 4. — Lowering [Ca²⁺]_e reduced the capacity of wild type and HyperKPP EDL to maintain a plateau phase at elevated [K⁺]_e. Fade represents the force drop after peak force had been reached, was calculated as the difference in force between peak force and the force at 200 ms (end of the stimulation period), and was expressed as a percentage of the peak force. Changes in [K⁺]_e and [Ca²⁺]_e were according to protocol 1. The control fade–[K⁺]_e relationship (i.e., no salbutamol [SAL]) was obtained using the force measured 45 min after the increase in [K⁺]_e (time 50 min; Fig. 1). The fade–[K⁺]_e relationship in the presence of 5 µM salbutamol was obtained using the force measured 10 min after the salbutamol addition. Vertical bars represent the SE of five to nine muscles. ^§, [K⁺]_e at which mean fade became significantly greater than at 4.7 mM K⁺. *, Mean fade was significantly different from that at 2.4 mM Ca²⁺. ¥, Significant effect of salbutamol. ANOVA and LSD, P < 0.05.