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. 2020 Jul 3;10:11010. doi: 10.1038/s41598-020-66981-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation analysis between cardiovascular score and anti-PC or anti-MDA antibody levels. (a) The levels of anti-PC and anti-MDA IgM compared for each disease independently with the cardiovascular score. Individual values are shown as dots with the linear trend lines indicated. Spearman’s rank correlations were estimated between these values. Negative correlation between IgM level and CV was detected for anti-PC but not for anti-MDA for MCTD, SLE, UCTD and RA. No significant correlations were shown for SSc, PAPs and SjS subsets. The total all-disease cohort also demonstrated significant negative correlation between anti-PC IgM and CV (rho −0.128, 2-sided p-value 1.27e-06), but not for anti-MDA (rho −0.042, 2-sided p-value 0.106). (b) Cardiovascular comorbidities and symptoms for all cases. The levels of anti-PC and anti-MDA IgM compared for all cases of systemic autoimmune diseases with the cardiovascular score. Individual values are shown as dots with the linear trend lines indicated. Spearman’s rank correlations were estimated between these values. Negative correlation between IgM level and CV was detected for anti-PC but not for anti-MDA.