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. 2020 Jul 3;11:3294. doi: 10.1038/s41467-020-17089-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Enrichment of the top 25 canonical pathways (a) and 3 disease networks (b) among genes implicated through promoter-open chromatin connectomes in TFH as measured by one-sided Fisher exact test in the IPA platform. c Regulatory hierarchical network from SLE-connectome-implicated genes. Color gradients in b, c represent log2 expression changes between TFH and naive T cells, with green indicating downregulation and red indicating upregulation in TFH. Blue nodes in c represent regulatory hubs for genes with no SLE-OCR connectome detected.