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. 2020 Jul 3;10:11017. doi: 10.1038/s41598-020-67291-0

Figure 2.

Figure 2

NBCn1 KO neurons have a higher action potential threshold. (A,B) Representative first action potentials evoked from somatic current injection in WT and KO neurons. Whole-cell recordings in a current clamp configuration were performed to identify the first action potential with a sharp and upward depolarization. (C) Action potential threshold. Values were obtained from 9 WT mice and 6 KO mice. **p < 0.01 compared to WT mice. (D) Input resistance (Rm). Rm was determined by the slope of a best-fit line in a voltage-current plot. (E) Resting membrane potential (Vm). The membrane voltage in the absence of current injection was determined (n = 9 WT mice and 7 KO mice). *p = 0.02 compared to WT.