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. 2020 Jul 3;11:3303. doi: 10.1038/s41467-020-17150-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic of circulating tumor cell purification, via removal of erythrocytes and platelets followed by efficient magnetophoretic depletion of labeled leukocytes, utilizing the CTC-iChip. b Heatmap of log₁₀(RPM+1) mRNA expression of keratin and mucin genes in CTCs purified from the blood of patients with localized PDAC (locPDAC, n = 17), and metastatic PDAC (metPDAC, n = 18) compared with healthy donor (HD, n = 21) controls. c Box plots showing expression of 4 mucin genes detected in cells released from localized PDAC and metastatic PDAC. *FDR < 0.10 relative to HDs of DESeq2-normalized data; n = 21 HD, 17 locPDAC, 18 metPDAC; median and 25–75% IQR shown by box plots. d Venn diagram of genes upregulated (17 locPDAC and 18 metPDAC compared with specimens from 21 HD controls; *FDR < 0.10) in localized PDAC and metastatic PDAC CTCs; “Hallmark” gene set ontology terms for each group are shown. + Denotes common ontology terms shared between both groups.