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. 2020 Jul 3;10:10994. doi: 10.1038/s41598-020-67910-w

Table 1.

The definition of various clinical indications.

Clinical indications Definition
NS 24-h urine protein ≥ 3.5 g with edema, accompanied by serum albumin < 30 g/L, hyperlipidemia
Nephritic syndrome 24-h urine protein between 1.5 and 3.5 g with hematuria, with or without high blood pressure and edema
ANS Abrupt onset of hematuria, hypertension, edema, oliguria and reduced eGFR
RPGN Acute nephritic syndrome with acute deteriorated renal function such as a twofold increase in serum creatinine concentration or a decrease in creatinine clearance by 50%
AUA Microscopic hematuria and /or subnephrotic proteinuria with no clinical symptoms or signs
AKI SCr increase ≥ 0.3 mg/dl (≥ 26.5 umol/L) within 48 h or SCr increased by ≥ 1.5 times the baseline value within the prior 7 days or urinary output < 0.5 ml/kg/h for 6 h
CKD eGFR < 60 mL/min/1.73 m2 or > 60 mL/min/1.73 m2 with urine albumin creatinine ratio (UACR) > 3 mg/mmol for ≥ 3 months

NS nephrotic syndrome, ANS acute nephritic syndrome, RPGN rapidly progressive renal glomerulonephritis, AUA asymptomatic urinary abnormalities, AKI acute kidney injury, CKD chronic kidney disease.