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. 2020 Jul 3;11:3364. doi: 10.1038/s41467-020-16734-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Top: predictive fibers calculated on both training cohorts (Cologne & Grenoble) irrespective of their target. Red fibers are positively associated with clinical improvement, blue fibers negatively. Bottom: the sum of aggregated fiber T-scores under each VTA predicted %-Y-BOCS improvements in eight patients with four settings each (N = 32 stimulations) of the Madrid cohort (left) and six patients of the London cohort with dual stimulation (four electrodes) of STN and ALIC (right). Gray shaded areas represent 95% confidence intervals. Please note that p-values in this manuscript are based on random permutation testing. Based on classical tests, the result shown in the lower right panel would remain significant in a one-sided test, only (p-one-sided = 0.044, p-two-sided = 0.089). A replication of this result based on anatomically predefined pathways is shown in Supplementary Fig. 2.