Table 2.
DBS targets for treatment of OCD defined in the literature.
DBS target | References | Number of patients | % Y-BOCS change | AC/PC coordinates | Relative to | Target type | MNI coordinates (Fig. 5) |
---|---|---|---|---|---|---|---|
STN | Mallet et al.66 | 8 | 32.1 | NA | AC | Tip of the electrode | ±11.30 −9.90 −7.81 |
amGPi | Nair et al.9 | 4a | NA | ±14.47 9.85 −3.28 | MCP | Tip of the electrode | ±15.66 −1.41 −8.22 |
VC/VS | Tsai et al.67 | 1 | 7.7 | ±7.5 16.3 −3.05 | MCP | Tip of the electrode | ±7.92 5.51 −9.01 |
slMFB | Coenen et al.10 | 2 | 41.7 (at 12 months) | ±7.6 −1.72 −3.0 | MCP | Active contacts | ±8.35 −13.64 −7.00 |
NAcc | Sturm et al.5 | 4 | NA | ±6.5 2.5 −4.5 | AC | Tip of the electrode | ±6.98 3.69 −10.55 |
ALIC | Nuttin et al.68 | 6 | 38.7 | ±13 3.5 0 | AC | Tip of the electrode | ±13.84 5.17 −5.04 |
MD | Maarouf et al.11 | 4 | 10.7 | ±4.7 −18.52 4.87 | AC | Active contacts | ±5.10 −18.17 2.59 |
VA | Maarouf et al.11 | 4 | 10.7 | ±6.84 −13.76 7.78 | AC | Active contacts | ±7.52 −12.68 5.60 |
iml | Maarouf et al.11 | 4 | 10.7 | ±5.78 −14.9 7.08 | AC | Active contacts | ±6.36 −13.99 4.85 |
ITP | Lee et al.69 | 5 | 52.0 | ±6.5 −3 −0.5 | AC | Tip of the electrode | ±6.92 −1.84 −5.13 |
BNST | Nuttin et al.70 | 4 | NA | ±6 0 0 | AC | Tip of the electrode | ±6.33 1.39 −4.87 |
MD medial dorsal thalamic nucleus, VA ventral anterior thalamic nucleus, iml internal medullary lamina, MCP mid-commissural point, AC anterior commissure.
aTourette patients, with prominent symptoms of OCD.