Table 1.

Symptomatic patients with CMV identified by rWGS pipeline.

Patient ID	CMV reads (#)	Age	Genetic diagnosis	Patient description	Standard care testing for CMV	TCP	Hep	AVT	Hearing test
Patient 1	3	8 d	Dursun syndrome	Profound neutropenia and cerebral infarct	NT	Yes	No	No	Passed
Patient 2	1,654	6 m	None found	Kaposiform hemangio-endothelioma with pneumocystis pneumonia	CMV plasma PCR negative. CMV serology positive. CMV in lungs on histopathology	Yes	Yes	No	NT
Patient 3	2	9 m	None found	Transient pancytopenia, megaloblastic	NT	Yes	No	No	NT
Patient 4	2	4 d	ASLD	Liver failure	NT	Yes	Yes	No	Passed
Patient 5	634	2 m	Ebstein anomaly	Ebstein anomaly status post heart transplant	Positive plasma PCR (1,892 IU/mL)	Yes	Yes	Yes	Passed
Patient 6	8	13 y	GPA	GPA with disseminated mucormycosis infection	Positive qualitative plasma PCR and bronchoalveolar lavage	Yes	Yes	No	NT

ASLD arginosuccinate lyase deficiency, D days, M months, Y years, GPA granulomatous polyangiitis, TCP thrombocytopenia, Hep. Hepatitis, AVT antiviral treatment, NT not tested.