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. 2020 Jul 3;11:3327. doi: 10.1038/s41467-020-17148-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Human cell engraftment 16-weeks post-transplantation in the bone marrow (BM), spleen (SP), and peripheral blood (PB) in transplants using CD68S-GCase-P2A-Citrine-targeted cells (n = 5 mice). b Modified allele frequency from engrafted CD68S-GCase-P2A-Citrine-targeted cells in the same tissues (n = 5 mice). c Percent human B-cell (CD19⁺), myeloid (CD33⁺), and monocyte (CD14⁺) populations in BM, SP, and PB shown in white. Citrine-positive cells in each population are shown in green (n = 5 mice). d Representative FACS plots showing gating strategy for mouse and human CD45⁺, CD45⁺/CD11b⁺, and CD45⁺/CD11b⁺/Citrine populations in macrophage preparations from lung, peritoneum, and liver. e Percent human CD45⁺ and human CD45⁺/Citrine cells in the same preparations (n = 5 mice). f Percent human CD45⁺/CD11b⁺ and human CD45⁺/CD11b⁺/Citrine cells in the same preparations (n = 5 mice). g Fold GCase activity in human Citrine⁺ cells compared to human Citrine⁻ cells in BM, SP, and lung (n = 3 mice). h Modified allele frequency in human Citrine⁺ cells (green) compared to human Citrine⁻ cells (white) in BM, SP, and lung in the same cells. a, b Median shown. c, e–g Data shown as mean ± SD. Source data are provided as a Source Data file.