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. 2020 Jul 3;10:10999. doi: 10.1038/s41598-020-67929-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The proteome maps obtained from two-dimensional proteome map analysis of plasma samples from the discovery bladder cancer patients/ healthy control cohorts. (A) A representative overlap 2D-DIGE image. The differentially expressed spots are denoted by arrows. (B) Images for low grade tumor, healthy control and internal standard were labeled with Cy3, Cy5 and Cy2 dyes respectively. (C) Panel depicted an example of protein spot 755 (Integrator complex subunit 10) abundance by 2D and 3D overexpressed in tumor compared to control.